Mark Zaidel specializes in intelligent information retrieval, content administration and designing web applications. He participated or lead development of data processing applications, content expert and multimedia systems that are used to create multimedia rich presentations, tutorials, and lectures for undergraduate, graduate and adult education. He has professional knowledge and working experience related to network design and administration in the university settings.

His sponsored and academic research has covered a variety of areas including intelligent knowledge management, assessment techniques in education, learning objects, interactive multimedia systems, artificial intelligence agents in computer-supported education, high speed networking, optimization algorithms, investment strategies, industry and technology forecasting and image visualization. Pattern recognition in textual content, clustering algorithms in natural language processing and utilizing AI algorithms in computer supported teaching are currently his main focus areas.